From Sanger to next-generation and long-read sequencing — explore key DNA sequencing technologies from Illumina, PacBio, BGI, Ion Torrent, and Oxford Nanopore and find the best platform for your study.

High-quality RNA is crucial for successful RNA-seq. This article covers the first steps of the workflow—experimental design, choosing the right extraction method, and handling different sample types like tissues, FFPE, blood, and plants—to help ensure RNA integrity and reliable downstream results.

From the early days of Sanger sequencing to the rise of next-generation platforms, DNA and RNA sequencing have transformed science and medicine. This article explores the history of sequencing technology, major applications like variant analysis, epigenomics, and clinical genomics, and walks through the full NGS workflow with practical tips for quality and accuracy.

Impurities in DNA and RNA prep can derail PCR, NGS, transcriptomics, and other molecular workflows. Even with good extraction protocols, detergents, salts, enzymes, and solvents often persist and require cleanup. This article walks through common purification methods—like silica columns, magnetic beads, ethanol precipitation, and phenol-chloroform—and explains their limitations. It also highlights newer solutions that speed cleanup and improve purity for sensitive downstream applications.

High-quality DNA and RNA are essential for NGS, transcriptomics, and molecular assays—but yield alone isn’t enough. Purity and integrity determine whether a sample will perform in downstream applications. This article explains what “quality” really means, how to assess contamination and degradation, and why the right QC methods protect your results.